GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs7589728 | 1 | rs12473740 | chr2:88527647 | THNSL2 | chr2:88469835-88486145:+ | -0.5 | -4.18 | 6.38E-5 | Plasma clusterin levels |
| THYM | cis | rs9876781 | 1 | rs12487542 | chr3:48426076 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.38 | 3.02E-5 | Longevity |
| THYM | cis | rs9847710 | 1 | rs12488768 | chr3:53086234 | ITIH4 | chr3:52847007-52866554:- | 0.27 | 4.18 | 6.51E-5 | Ulcerative colitis |
| THYM | cis | rs10935120 | 1 | rs12490835 | chr3:134223730 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.05 | 2.33E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs12490835 | chr3:134223730 | CEP63 | chr3:134204575-134293852:+ | 0.4 | 5.81 | 8.19E-8 | Height |
| THYM | cis | rs11723261 | 1 | rs12505835 | chr4:297525 | ZNF718 | chr4:53272-156488:+ | 0.63 | 6.87 | 6.5E-10 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs2275426 | 1 | rs12561806 | chr1:46396776 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs12564541 | chr1:46380237 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs4237643 | 1 | rs12577464 | chr11:43662440 | HSD17B12 | chr11:43702143-43878160:+ | -0.58 | -5.99 | 3.71E-8 | Forced vital capacity |
| THYM | cis | rs9902453 | 1 | rs12600855 | chr17:28279591 | EFCAB5 | chr17:28256874-28435469:+ | 0.31 | 4.26 | 4.79E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs9902453 | 1 | rs12600993 | chr17:28291222 | EFCAB5 | chr17:28256874-28435469:+ | 0.31 | 4.26 | 4.79E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs3820928 | 1 | rs12615988 | chr2:227769000 | RHBDD1 | chr2:227700773-227861591:+ | -0.31 | -4.56 | 1.54E-5 | Pulmonary function |
| THYM | cis | rs10935120 | 1 | rs12637751 | chr3:134266124 | ANAPC13 | chr3:134196547-134204865:- | -0.59 | -8.13 | 1.58E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs12637751 | chr3:134266124 | CEP63 | chr3:134204575-134293852:+ | -0.41 | -5.87 | 6.33E-8 | Height |
| THYM | cis | rs9815354 | 1 | rs12639255 | chr3:41861738 | ULK4 | chr3:41288091-42003660:- | 1 | 10.81 | 3.16E-18 | Diastolic blood pressure |